Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor
To the Editor: Several points in the study
by Dr Leape and colleagues1 require clarification.
How were the ADEs not recorded in the chart captured by the investigators?
How many of the nonpreventable ADEs were idiosyncratic reactions? The rate
of preventable ordering ADEs, when calculated in terms of the number of patient
admissions to the study unit, appears to have decreased from 14.6% and not
12% as stated. Would the use of total, or per-patient, drug doses ordered
in the denominator allow more uniform comparison with intensive care units
(ICUs) of differing case mix? We find the ADE rate described similar to our
own. Of 441 recently documented ADEs in our institution, 109 occurred in the
ICUs, 49% of which were considered preventable.
Boullata JI, McDonnell PJ. Preventing Medication Errors in the Intensive Care Unit. JAMA. 2000;283(10):1287-1289. doi:10.1001/jama.283.10.1287