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March 15, 2000

Bisphosphonate Therapy and Vascular Calcification

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(11):1424-1425. doi:10.1001/jama.283.11.1421

To the Editor: The 3-year, randomized controlled trial reported by Dr Harris and colleagues1 demonstrated that risedronate increased bone mineral density and decreased fracture incidence in postmenopausal women with established osteoporosis. Although the overall safety profile was similar in the placebo and risedronate groups, serious adverse events were more common in the treatment group.

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