Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor
Copyright 2000 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2000
In Reply: The first article1
Drs Benigni and Remuzzi refer to is not a study of preeclampsia. It found
that low-dose aspirin reduces TxB2 but not PGI2 in women
"at risk for pregnancy-induced hypertension."1
The authors specifically note, "The only patient with proteinuria . . . had
a glomerular disease before her pregnancy." Thus, Benigni et al do not provide
any information on eicosanoid change in preeclamptic women. In fact, only
3 of the 33 women in their "at risk for pregnancy-induced hypertension" group
actually developed pregnancy-induced hypertension.
Mills JL, Levine RJ, Morrow JD. Prostacyclin and Thromboxane and the Development of Preeclampsia—Reply. JAMA. 2000;283(12):1568-1569. doi:10.1001/jama.283.12.1563