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April 12, 2000

Increased Bioavailability of Sildenafil in Mexican Men

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Fishbein FellowIndividualAuthor

JAMA. 2000;283(14):1825-1826. doi:10.1001/jama.283.14.1821

To the Editor: Some studies suggest that drug metabolism by Cytocrome P 3A4 450 (CYP3A4) differs by ethnic group. Nifedipine1 and midazolam,2 drugs considered to be markers of CYP3A4 activity, exhibit reduced clearance and higher bioavailability in Mexican men compared with white men. Sildenafil (Viagra, Pfizer Inc, New York, NY), a popular drug for the treatment of erectile dysfunction, is also biotransformed by CYP3A4.3 Therefore, we studied the pharmacokinetics of oral sildenafil in 24 healthy, young, male Mexican volunteers for 12 hours after a 100-mg dose.

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