Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Contributing EditorIndividualAuthor
Copyright 2000 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2000
To the Editor: Nitric oxide–mediated
damage has been implicated in a number of neurological diseases including
stroke1,2 and multiple
sclerosis (MS).3 For instance, monocytes
expressing high levels of nitric oxide synthetase have been found in plaques
from the brains of patients with MS.4 The
proximal agent of neuronal cell damage may be peroxynitrite, which is formed
in vivo from the synthesis of nitric oxide and superoxide.
Kanabrocki EL, Third JLHC, Ryan MD, Nemchausky BA, Shirazi P, Scheving LE, McCormick JB, Hermida RC, Bremner WF, Hoppensteadt DA, Fareed J, Olwin JH. Circadian Relationship of Serum Uric Acid and Nitric Oxide. JAMA. 2000;283(17):2240-2241. doi:10.1001/jama.283.17.2235