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May 3, 2000

Circadian Relationship of Serum Uric Acid and Nitric Oxide

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;283(17):2240-2241. doi:10.1001/jama.283.17.2235

To the Editor: Nitric oxide–mediated damage has been implicated in a number of neurological diseases including stroke1,2 and multiple sclerosis (MS).3 For instance, monocytes expressing high levels of nitric oxide synthetase have been found in plaques from the brains of patients with MS.4 The proximal agent of neuronal cell damage may be peroxynitrite, which is formed in vivo from the synthesis of nitric oxide and superoxide.

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