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June 7, 2000

Improving the Conduct and Reporting of Clinical Trials—Reply

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;283(21):2787-2790. doi:10.1001/jama.283.21.2787

In Reply: Dr Bernhardt refers to a study that should have shown that nystatin is effective against esophageal candidiasis, but this study is an evaluation of 2537 endoscopies and not a randomized trial.1 We showed that the effect of nystatin is similar to that of placebo in immunocompromised patients. Despite this outcome, the results for amphotericin B and nystatin had been combined in 3 of the large trials we identified for our meta-analysis.

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