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June 7, 2000

Improving the Conduct and Reporting of Clinical Trials—Reply

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Contributing EditorIndividualAuthor


Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

JAMA. 2000;283(21):2787-2790. doi:10.1001/jama.283.21.2787

In Reply: Dr Bernhardt refers to a study that should have shown that nystatin is effective against esophageal candidiasis, but this study is an evaluation of 2537 endoscopies and not a randomized trial.1 We showed that the effect of nystatin is similar to that of placebo in immunocompromised patients. Despite this outcome, the results for amphotericin B and nystatin had been combined in 3 of the large trials we identified for our meta-analysis.

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