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June 14, 2000

Statins and Risk of Coronary Heart Disease

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;283(22):2935. doi:10.1001/jama.283.22.2931

To the Editor: Dr LaRosa and colleagues1 have calculated the number needed to treat (NNT) from pooled estimates of the absolute risk differences from 5 trials of statins. The NNT is commonly used to summarize the effects of treatment in a clinically relevant way, taking into account both baseline risk without treatment and the risk reduction achieved with treatment. However, the NNT derived from pooled estimates of treatment effects may be seriously misleading.2 This is because the NNT is sensitive to factors that change baseline risk, including the outcome considered, characteristics of patients included in trials, secular trends in incidence and case-fatality, and the clinical setting. In the statin trials included in the meta-analysis, baseline coronary heart disease mortality risk, estimated from the control group event rates, varies by more than an order of magnitude (Table 1), making the pooled NNT uninterpretable.

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