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June 14, 2000

Effect of Ritonavir on Saquinavir Metabolism

Author Affiliations

Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;283(22):2936-2937. doi:10.1001/jama.283.22.2931

To the Editor: The Consensus Statement on antiretroviral therapy in adults by Dr Carpenter and colleagues1 contains an inaccuracy regarding the effect of coadministration of ritonavir on the exposure of saquinavir in the soft-gelatin formulation (saquinavir SGF). Table 2 states that ritonavir coadministration results in an increase in saquinavir exposure (area under the plasma concentration curve [AUC]) of 121%. This estimate, however, is too low by greater than an order of magnitude.2

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