Phil B.FontanarosaMD, Deputy EditorIndividualAuthorStephen J.LurieMD, PhD, Contributing EditorIndividualAuthor
Copyright 2000 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2000
In Reply: We agree that there should be attention
to dose adjustments for drug combinations (including saquinavir SGF and ritonavir)
for which there are substantial effects on the metabolism of one drug by the
other. The data in our table are accurate as presented and are as cited in
the current (2000) package insert for saquinavir SGF.1
However, the more recent data described by Dr Buss2
using a higher dose of saquinavir SGF (800 mg, twice daily) in combination
with ritonavir, 200 or 400 mg, twice daily, found increases in AUCs for saquinavir
SGF of 1589% and 2158%, respectively. Both sets of data are accurate but represent
different dosing regimens of the saquinavir SGF and ritonavir combination.
Table 2 of our article provides some examples of possible dose changes in
Carpenter CCJ. Effect of Ritonavir on Saquinavir Metabolism—Reply. JAMA. 2000;283(22):2936-2937. doi:10.1001/jama.283.22.2931