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June 21, 2000

Antiviral Agents for Influenza

Author Affiliations
  • 1University of Minnesota and Veterans Affairs Medical Center, Minneapolis
JAMA. 2000;283(23):3069-3070. doi:10.1001/jama.283.23.3068c

To the Editor: Dr Wenzel's Editorial1 regarding anti-influenza drugs could be interpreted as dismissing the "first-generation" agents amantadine and rimantadine in favor of the newer "second-generation" neuraminidase inhibitors oseltamivir and zanamivir. Following a brief mention of the approved indications for the older agents, he provides a detailed list of the limitations of amantadine and rimantadine. The implication seems to be that the older agents are flawed and obsolete.

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