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July 12, 2000

Quality of Life in Maintenance vs Prolonged Induction Therapy for HIV

Author Affiliations

Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;284(2):178-179. doi:10.1001/jama.284.2.175

To the Editor: The feasibility of induction-maintenance therapy for human immunodeficiency virus type 1 (HIV) infection has been studied as a strategy to simplify antiretroviral regimens.13 In the Amsterdam Duration of Antiretroviral Medication study, maintenance dual therapy after 26 weeks of quadruple induction therapy resulted in less viral suppression than prolonged induction therapy.3 However, a prolonged quadruple regimen may have a negative impact on patients' quality of life (QOL) because of pill burden and adverse effects. We compared QOL in maintenance vs prolonged induction therapy.

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