Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthor
To the Editor: The feasibility of induction-maintenance
therapy for human immunodeficiency virus type 1 (HIV) infection has been studied
as a strategy to simplify antiretroviral regimens.1- 3
In the Amsterdam Duration of Antiretroviral Medication study, maintenance
dual therapy after 26 weeks of quadruple induction therapy resulted in less
viral suppression than prolonged induction therapy.3
However, a prolonged quadruple regimen may have a negative impact on patients'
quality of life (QOL) because of pill burden and adverse effects. We compared
QOL in maintenance vs prolonged induction therapy.
Fontanarosa PB, Nieuwkerk PT, Reijers MHE, Weigel HM, Lange JMA, Sprangers MAG. Quality of Life in Maintenance vs Prolonged Induction Therapy for HIV. JAMA. 2000;284(2):178-179. doi:10.1001/jama.284.2.175