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July 12, 2000

Directly Observed Therapy to Treat HIV Infection in Prisoners

Author Affiliations

Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;284(2):179-180. doi:10.1001/jama.284.2.175

To the Editor: The efficacy of highly active antiretroviral therapy (HAART) in the treatment of human immunodeficiency virus (HIV) infection has been demonstrated in a number of clinical reports.1 However, current regimens are complex and poor adherence to therapy is the main cause of both treatment failure and emergence of drug resistance.2 Adherence to multidose treatment regimens may be more difficult in certain settings, such as prison.3 Herein we report data from HIV-positive prisoners treated using a directly observed therapy (DOT) program.4 To our knowledge, DOT for HIV infection has not been evaluated in this setting.

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