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July 19, 2000

Estrogen as a Treatment for Alzheimer Disease

Author Affiliations

Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;284(3):307-308. doi:10.1001/jama.284.3.303

To the Editor: The negative results of ERT reported by Dr Mulnard and colleagues1 in patients with mild to moderate AD have to be interpreted within the context of the mechanism of estrogen action in the central nervous system. The therapeutic potential of estrogen did not receive a fair evaluation because the experimental design failed to take this information into account. The sample comprised elderly women with AD with previous hysterectomies. These women were likely to have been profoundly deprived of estrogen, possibly for decades, because of the oophorectomy that generally accompanies hysterectomy.

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