Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthor
Copyright 2000 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2000
To the Editor: The negative results of ERT
reported by Dr Mulnard and colleagues1 in
patients with mild to moderate AD have to be interpreted within the context
of the mechanism of estrogen action in the central nervous system. The therapeutic
potential of estrogen did not receive a fair evaluation because the experimental
design failed to take this information into account. The sample comprised
elderly women with AD with previous hysterectomies. These women were likely
to have been profoundly deprived of estrogen, possibly for decades, because
of the oophorectomy that generally accompanies hysterectomy.
Fontanarosa PB, Toran-Allerand CD. Estrogen as a Treatment for Alzheimer Disease. JAMA. 2000;284(3):307-308. doi:10.1001/jama.284.3.303