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July 19, 2000

Prognostic Value of Cortisol Response in Septic Shock

Author Affiliations

Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;284(3):308-309. doi:10.1001/jama.284.3.303

To the Editor: Dr Annane and colleagues1 found that in patients with septic shock, a high baseline serum cortisol level (>34 µg/dL), or a maximum increase in stimulated cortisol concentration of ≤9 µg/dL (following high-dose cosyntropin testing), or both predicts a higher mortality. We believe that many of the hypotheses on which this study is based may be incorrect.

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