Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthor
To the Editor: Dr Annane and colleagues1 found that in patients with septic shock, a high
baseline serum cortisol level (>34 µg/dL), or a maximum increase in
stimulated cortisol concentration of ≤9 µg/dL (following high-dose
cosyntropin testing), or both predicts a higher mortality. We believe that
many of the hypotheses on which this study is based may be incorrect.
Fontanarosa PB, Marik P, Zaloga G. Prognostic Value of Cortisol Response in Septic Shock. JAMA. 2000;284(3):308-309. doi:10.1001/jama.284.3.303