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July 19, 2000

Prognostic Value of Cortisol Response in Septic Shock

Author Affiliations

Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthor

JAMA. 2000;284(3):308-309. doi:10.1001/jama.284.3.303

To the Editor: Dr Annane and colleagues1 demonstrate that in patients with early septic shock, high plasma cortisol levels and diminished response to corticotropin stimulation correlate with a poor outcome. This finding expands on previous work, which showed that administration of exogenous steroids in early septic shock was associated with decreased survival.2

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