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August 9, 2000

Estrogen-Progestin Replacement and Risk of Breast Cancer

Author Affiliations

Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor


Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

JAMA. 2000;284(6):691-694. doi:10.1001/jama.284.6.691

To the Editor: Dr Schairer and colleagues1 reported an RR for breast cancer of 1.4 for women who had used estrogen-progestin replacement therapy for 4 years compared with women who had never used estrogen or progestin therapy. This equates to a 40% increase in the risk of breast cancer, a figure that was seized on and widely reported by the media.

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