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August 9, 2000

Estrogen-Progestin Replacement and Risk of Breast Cancer—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(6):691-694. doi:10.1001/jama.284.6.691

In Reply: We appreciate this opportunity to clarify and expand our results. In response to concerns that the patterns of hormone use in our patient population were atypical, we note that among hormone users in our study the percentage of person-years associated with estrogen-progestin use increased from 7% to 37% from 1979-1983 to 1992-1995. The figure for the later period compares with results from a nationally representative cohort in which 31% of women interviewed in 1992 who had used HRT received progestin.1

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