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August 9, 2000

Serologic Testing for Lyme Disease—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Contributing EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(6):695-696. doi:10.1001/jama.284.6.691

In Reply: In their letter, Dr Schriefer and colleagues compare a relatively large study to a smaller pilot study that uses a different method and then compare the immune complex data from the pilot study to free antibody data in their laboratory. They contrast our 95% true-positive rate of Borrelia burgdorferi–specific immune complex assay in more than 158 patients with Lyme disease who were stratified into groups with a 52% true-positive rate in their pilot study of 13 patients, also stratified into groups.

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