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September 27, 2000

Relationship Between Glucose Metabolism and Pancreatic Cancer—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(12):1512. doi:10.1001/jama.284.12.1512

In Reply: As suggested by Dr Kulkarni, a positive association between high postload plasma glucose concentration and hepatobiliary cancer is biologically plausible and may be related to activation of the insulin-like growth factor receptor. Indeed, Lagiou et al1 recently reported nearly a 1.9-fold greater risk of liver cancer among individuals with diabetes. While analysis of the relationship between postload plasma glucose concentration and liver cancer was not an original goal of our research, we now plan to explore this association in the Chicago Heart Association Detection Project in Industry.

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