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October 11, 2000

Quality of Evidence for Treatment of Prostate Cancer—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor


Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

JAMA. 2000;284(14):1785-1786. doi:10.1001/jama.284.14.1783

In Reply: Dr Clarke highlights the importance of systematic reviews of RCTs for providing a reliable summary of the evidence so that patients and physicians can make well-informed medical decisions. High-quality systematic reviews efficiently integrate information and provide data for rational decision making. They establish whether findings are consistent and can be generalized or whether findings vary by subsets. Meta-analyses, where appropriate, can increase power and precision to enhance estimates of treatment effects and exposure risk.1

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