Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor
In Reply: Although the association between
high parity and increased risk of type 2 diabetes is not well established,
it is certainly a plausible confounder because the effect of pregnancy may
mediate this relationship through increased weight gain or other independent
pathways. In our study, women were asked to report their number of pregnancies.
Additional analyses indicate that this variable was associated both with race
and diabetes risk. In general, African American women had a greater number
of pregnancies than white women (median numbers of pregnancies were 4 for
African American women and 3 for white women). In addition, greater parity
was associated with higher diabetes risk (RR, 1.12 per pregnancy; 95% confidence
interval [CI], 1.09-1.15).
Brancati FL, Kao WHL, Szklo M, Folsom AR, Watson RL. Race, Parity, and Gestational Diabetes as Risk Factors for Type 2 Diabetes Mellitus—Reply. JAMA. 2000;284(18):2318-2319. doi:10.1001/jama.284.18.2317