Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor
To the Editor: Dr Biggar and colleagues1 recently reported elevated risks of cancer in children
with AIDS (acquired immunodeficiency syndrome). As contributors of data to
this study, we have several concerns about the authors' conclusions.
First, the authors did not measure the effect of perinatal antiretroviral
therapy exposure on the relationship between HIV (human immunodeficiency virus)
infection and cancer. However, some AIDS registries contain data on perinatal
antiretroviral exposure. Evaluation of these data would help confirm that
cancer incidence is not related to antiretroviral exposure.
Gallagher B, Wang Z. Estimating the Risk of Cancer in Children With AIDS. JAMA. 2000;284(20):2593-2594. doi:10.1001/jama.284.20.2591