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December 6, 2000

Adverse Effects Associated With Use of Nevirapine in HIV Postexposure Prophylaxis for 2 Health Care Workers

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(21):2722-2723. doi:10.1001/jama.284.21.2717

To the Editor: Current guidelines from the US Centers for Disease Control and Prevention concerning PEP for HIV-exposed health care workers recommend the use of combination antiretroviral therapy with 2 to 3 medications, depending on the extent of exposure and source patient characteristics.1 While the risk of transmission of HIV via a needlestick is approximately 0.3%, the risk of serious adverse effects of these preventive strategies remains undefined.1 We report a case of a health care worker who experienced serious morbidity from PEP.

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