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December 13, 2000

Biochemical Outcomes of Treatment for Prostate Cancer—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(22):2869. doi:10.1001/jama.284.22.2869

In Reply: In our article, we raised all of the concerns stated by Dr Vicini and colleagues. We stated that the median follow-up was relatively short, that the Radiation Therapy Oncology Group1 and the European Organization for Research in the Therapy of Cancer2 have documented a benefit in survival for up to 3 years of adjuvant AST in patients with locally advanced (not clinically localized) prostate cancer, that "no conclusions can be drawn from a nonrandomized retrospective comparison," and that "Results from prospective randomized trials currently underway are needed to validate these findings."

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