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December 13, 2000

Antiretroviral Therapy and Mortality Among Children With Perinatal HIV Infection—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(22):2871-2872. doi:10.1001/jama.284.22.2869

In Reply: Mr Teglas and colleagues raise the important issue of selection bias in longitudinal studies to estimate the survival of HIV-infected individuals and suggest that our study's estimated cumulative probability of survival, which is lower than that reported elsewhere, may have been affected by such a bias. Although we agree that enrolling all children at birth would represent an improvement, the ideal study would enroll a very large sample of HIV-infected women and follow up those who became pregnant and, afterward, their children.

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