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December 27, 2000

Lead in Calcium Supplements—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(24):3126. doi:10.1001/jama.284.24.3123

In Reply: In response to Dr Ross and colleagues, my statement about interference of calcium in lead absorption, while supported and predicted by animal studies, was based on studies in humans. At a population level, blood lead concentration is inversely correlated with reported calcium intake.1,2 In controlled experiments, absorption of tracer-labeled lead sources is reduced by factors of 6- to 50-fold by coingestion of calcium.3,4

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