Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor
To the Editor: Dr Guyatt and colleagues1 suggest a hierarchy of study design to evaluate
the strength of evidence for making treatment decisions. In promoting the
superiority of single randomized trials over systematic reviews of observational
studies, the authors risk making the same mistake that evidence-based medicine
professes to avoid—relying on personal experience and disregarding the
best available evidence.
Shah NR. What Is the Best Evidence for Making Clinical Decisions?. JAMA. 2000;284(24):3127-3128. doi:10.1001/jama.284.24.3123