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December 27, 2000

What Is the Best Evidence for Making Clinical Decisions?

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor


Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2000

JAMA. 2000;284(24):3127-3128. doi:10.1001/jama.284.24.3123

To the Editor: Dr Guyatt and colleagues1 suggest a hierarchy of study design to evaluate the strength of evidence for making treatment decisions. In promoting the superiority of single randomized trials over systematic reviews of observational studies, the authors risk making the same mistake that evidence-based medicine professes to avoid—relying on personal experience and disregarding the best available evidence.

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