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Letters
December 27, 2000

Association of Initial CD4 Cell Count and Viral Load With Response to Highly Active Antiretroviral Therapy

Author Affiliations
 

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorPhil B.FontanarosaMD, Executive Deputy EditorIndividualAuthor

JAMA. 2000;284(24):3128-3129. doi:10.1001/jama.284.24.3123

To the Editor: Considerable uncertainty and debate exist regarding the appropriate time for initiating antiretroviral therapy for the treatment of HIV (human immunodeficiency virus).1 British guidelines suggest that treatment should be initiated based on CD4 cell count alone,2 while US guidelines recommend treatment based on a CD4 cell count below 500/mm3 or a viral load above 10 000 to 20 000 per mL.3,4 No prospective study of starting vs delaying the initiation of highly active antiretroviral therapy in patients with higher viral loads has been performed.

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