Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor
To the Editor: There have now been 3 randomized controlled trials investigating the effectiveness of influenza vaccine in preventing sick leave by healthy working adults.1- 3 Two trials1,2 explicitly calculated the cost-effectiveness of vaccine provision but appear to give conflicting results. The relative newness of randomized cost-effectiveness trials is reflected in several unresolved methodological issues, which we believe to be the source of the disagreement.
Byrnes GB, Kelly H. Influenza Vaccine for Healthy Working Adults. JAMA. 2001;285(3):290-292. doi:10.1001/jama.285.3.290