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January 17, 2001

Influenza Vaccine for Healthy Working Adults

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthor

JAMA. 2001;285(3):290-292. doi:10.1001/jama.285.3.290

To the Editor: There have now been 3 randomized controlled trials investigating the effectiveness of influenza vaccine in preventing sick leave by healthy working adults.13 Two trials1,2 explicitly calculated the cost-effectiveness of vaccine provision but appear to give conflicting results. The relative newness of randomized cost-effectiveness trials is reflected in several unresolved methodological issues, which we believe to be the source of the disagreement.

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