Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
In Reply: We described another potential complication of MDMA abuse. It is not logical to suggest that by describing possible dextromethorphan toxicity we somehow minimize the dangers of illicit MDMA. The adverse effects of MDMA are well-documented and well-known to medical personnel. We reluctantly omitted an explicit comparison of MDMA and dextromethorphan toxicity due to space constraints but strongly agree that both drugs may produce toxic syndromes with similar signs and symptoms. We also agree that currently available qualitative urine toxicology screening systems may not detect MDMA in as many as one third of samples.
Mendelson J. Dextromethorphan and Ecstasy Pills—Reply. JAMA. 2001;285(4):409-410. doi:10.1001/jama.285.4.407