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January 24/31, 2001

Dextromethorphan and Ecstasy Pills—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor


Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

JAMA. 2001;285(4):409-410. doi:10.1001/jama.285.4.407

In Reply: We described another potential complication of MDMA abuse. It is not logical to suggest that by describing possible dextromethorphan toxicity we somehow minimize the dangers of illicit MDMA. The adverse effects of MDMA are well-documented and well-known to medical personnel. We reluctantly omitted an explicit comparison of MDMA and dextromethorphan toxicity due to space constraints but strongly agree that both drugs may produce toxic syndromes with similar signs and symptoms. We also agree that currently available qualitative urine toxicology screening systems may not detect MDMA in as many as one third of samples.

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