Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
In Reply: We thank Dr Bendjelid and colleagues for their interesting hypothesis. As already stated, the main goal of our study was to enroll patients with acute lung injury. We expected that a small proportion of these patients with a history of cardiac disease would be eventually classified as having acute cardiac decompensation. Our study was thus underpowered to exclude a slight favorable effect of CPAP on acute cardiogenic edema. Prior studies of CPAP have generally not made a clear distinction between diastolic and systolic forms of left cardiac decompensation in cardiogenic pulmonary edema.
Delclaux C, Brochard L. Treatment of Respiratory Failure With Noninvasive Continuous Positive Airway Pressure—Reply. JAMA. 2001;285(7):880-881. doi:10.1001/jama.285.7.879