Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
To the Editor: Dr Rowe and colleagues1 examined the hypothesis that orthostasis contributes to the symptoms experienced by patients with CFS. They tested this hypothesis by treating patients with CFS with either fludrocortisone or placebo and found that there was no difference in symptoms in either group. Thus, their study corroborates the findings of Peterson et al,2 who also observed no differences in symptom scores in their crossover study comparing fludrocortisone and placebo.
Friedman TC, Echeverry D, Poland RE. Orthostatic Hypotension and Chronic Fatigue Syndrome. JAMA. 2001;285(11):1441-1443. doi:10.1001/jama.285.11.1441