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April 4, 2001

Chlamydia trachomatis and Cervical Squamous Cell Carcinoma

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;285(13):1703-1706. doi:10.1001/jama.285.13.1703

To the Editor: Dr Anttila and colleagues1 presented data linking Chlamydia trachomatis with cervical squamous cell carcinoma (SCC). However, because the serologic methods they used to measure human papillomavirus (HPV) infection are of limited sensitivity and narrow spectrum,2 the apparent increased risk of SCC associated with C trachomatis infections may be due to residual confounding caused by misclassification of the primary confounding variable, HPV. To assess C trachomatis as an independent cofactor in this study population, we suggest the analysis be restricted only to those women who are seropositive for HPV.

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