Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001
To the Editor: Dr Anttila and colleagues1 presented data linking Chlamydia trachomatis with cervical squamous cell carcinoma (SCC). However, because the serologic methods they used to measure human papillomavirus (HPV) infection are of limited sensitivity and narrow spectrum,2 the apparent increased risk of SCC associated with C trachomatis infections may be due to residual confounding caused by misclassification of the primary confounding variable, HPV. To assess C trachomatis as an independent cofactor in this study population, we suggest the analysis be restricted only to those women who are seropositive for HPV.
Gravitt PE, Castle PE. Chlamydia trachomatis and Cervical Squamous Cell Carcinoma. JAMA. 2001;285(13):1703-1706. doi:10.1001/jama.285.13.1703