Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
To the Editor: We previously demonstrated in vivo imaging of cell death in the myocardia of patients with acute myocardial infarction using technetium Tc 99m–labeled annexin-V (99mTc-p-annexin-V [Apomate], Theseus Imaging, Cambridge, Mass) and nuclear imaging.1 Because high proliferation and apoptotic indices have been reported in rapidly growing malignant tumors,2 information about the extent of apoptosis in the tumor may also provide insight into the tumor's biology and prognosis.
Hofstra L, Dumont EA, Thimister PWL, Heidendal GAK, DeBruine AP, Elenbaas TWO, Boersma HH, van Heerde WL, Reutelingsperger CPM. In Vivo Detection of Apoptosis in an Intracardiac Tumor. JAMA. 2001;285(14):1841-1842. doi:10.1001/jama.285.14.1841