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April 11, 2001

In Vivo Detection of Apoptosis in an Intracardiac Tumor

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;285(14):1841-1842. doi:10.1001/jama.285.14.1841

To the Editor: We previously demonstrated in vivo imaging of cell death in the myocardia of patients with acute myocardial infarction using technetium Tc 99m–labeled annexin-V (99mTc-p-annexin-V [Apomate], Theseus Imaging, Cambridge, Mass) and nuclear imaging.1 Because high proliferation and apoptotic indices have been reported in rapidly growing malignant tumors,2 information about the extent of apoptosis in the tumor may also provide insight into the tumor's biology and prognosis.

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