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April 25, 2001

Safety of Bolus vs Infusion Thrombolytic Therapy

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;285(16):2075. doi:10.1001/jama.285.16.2075

To the Editor: In their meta-analyses1,2 Dr Eikelboom and colleagues compare thrombolytic therapies for acute myocardial infarction (MI). Since meta-analyses of bolus-vs-infusion trials reveal no differences in efficacy, the choice of agent should be based on safety and cost. With regard to safety, the only statistically significant difference in the meta-analyses was a reduction in intracranial hemorrhages with infusion agents.1,2

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