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May 2, 2001

Chemical Andropause and Amyloid-β Peptide

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;285(17):2195-2196. doi:10.1001/jama.285.17.2195-a

To the Editor: Estrogen status appears to modify the risk of developing Alzheimer disease (AD).1 It has recently been proposed that this may be due to the effect of gonadal hormones on amyloid-β peptide (Aβ), which is the main neurotoxic component of cerebral amyloid found in AD.24 Furthermore, rising plasma Aβ levels have been found to be associated with incipient AD,5 and a genetically linked phenotype of elevated plasma Aβ levels appears to be related to the risk for late-onset AD.6 We studied the effect of gonadal hormone withdrawal in men on plasma levels of Aβ1-40.

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