Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
To the Editor: It has been reported that 80% of patients with primary biliary cirrhosis (PBC) experience generalized fatigue.1,2 Although fatigue can significantly affect quality of life, few studies have addressed its etiology in PBC. Some reports suggest that there may be a significant organic component to the fatigue described by patients with PBC,2 perhaps as a result of peripheral muscle dysfunction.3 We sought to examine the relationship between peripheral muscle dysfunction and fatigue in a larger sample of patients with PBC.
Goldblatt J, James OFW, Jones DEJ. Grip Strength and Subjective Fatigue in Patients With Primary Biliary Cirrhosis. JAMA. 2001;285(17):2196-2197. doi:10.1001/jama.285.17.2196