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May 2, 2001

Grip Strength and Subjective Fatigue in Patients With Primary Biliary Cirrhosis

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;285(17):2196-2197. doi:10.1001/jama.285.17.2196

To the Editor: It has been reported that 80% of patients with primary biliary cirrhosis (PBC) experience generalized fatigue.1,2 Although fatigue can significantly affect quality of life, few studies have addressed its etiology in PBC. Some reports suggest that there may be a significant organic component to the fatigue described by patients with PBC,2 perhaps as a result of peripheral muscle dysfunction.3 We sought to examine the relationship between peripheral muscle dysfunction and fatigue in a larger sample of patients with PBC.

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