Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
In Reply: In response to Dr Dixon, we designed the study in 8-week dosing intervals because these were sufficient to attain steady-state suppression of elevated urinary isoprostanes in patients with syndromes of oxidant stress and in animal models of disease.1,2 Steady-state circulating levels of vitamin E are attained much earlier than these pharmacodynamic responses. Clearly an impact on a chronic disease process in which lipid peroxidation may play a role, such as human atherosclerosis, may require longer periods of follow-up to assess clinical end points, even using contemporary approaches to measurement of plaque progression, such as electron beam computed tomography or magnetic resonance imaging.
FitzGerald GA, Meagher E. Vitamin E Supplementation in Healthy Persons—Reply. JAMA. 2001;285(19):2449-2450. doi:10.1001/jama.285.19.2449