To the Editor: In a recent Grand Rounds, Dr Gaine1 discussed a 44-year-old woman with primary pulmonary hypertension (PPH). After extensive investigations he associated her PPH with anorexigen use. However no information was provided on clinical or laboratory features of thyroid disease. An association between hypothyroidism and PPH has been reported. Curnock et al2 carried out a retrospective review of 41 patients with PPH; of the 40 patients studied, 9 (22.5%) had evidence of hypothyroidism.
Kashyap AS, Kashyap S. Thyroid Disease and Primary Pulmonary Hypertension. JAMA. 2001;285(22):2853-2854. doi:10.1001/jama.285.22.2853