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June 20, 2001

Hormonal Replacement Therapy and Cognition in Postmenopausal Women

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;285(23):2974-2975. doi:10.1001/jama.285.23.2974

To the Editor: In their review of studies on the effects of hormone replacement therapy (HRT) on cognitive function in postmenopausal women, Dr LeBlanc and colleagues1 concluded that HRT may improve specific aspects of cognitive functioning in women with menopausal symptoms (eg, hot flashes, sleep loss) but not in women who are asymptomatic. We do not believe that this conclusion is justified by the literature.

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