Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
To the Editor: Dr Shelton and colleagues1 conducted an 8-week intervention trial comparing
St John's wort extract with placebo for the treatment of major depression.
Ironically, their study was limited by the same criticisms they leveled against
previous studies of St John's wort—a flawed protocol and inappropriately
generalized findings. Shelton et al concluded that the herbal extract was
not effective for treatment of major depression, but their trial did not include
a prescription antidepressant arm to indicate whether the study was sensitive
enough to detect effectiveness.
Fomous CM, Cardellina II JH. St John's Wort and Major Depression. JAMA. 2001;286(1):42-45. doi:10.1001/jama.286.1.42