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July 11, 2001

Alcohol Use as a Prognostic Factor Following Myocardial Infarction

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(2):165. doi:10.1001/jama.286.2.165

To the Editor: Perhaps most of the findings of Dr Mukamal and colleagues1 could be explained by self-selection bias, which has presented a similar problem in studies of the association of estrogen use and cardiovascular disease. Data from at least 32 prospective and retrospective cohort studies showed that estrogen leads to reduction in risk of coronary artery disease.2 The Nurses' Health Study, which is the largest of such cohort studies, has reported an association of estrogen use with reduced cardiovascular risk, incidence, and mortality.3

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