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September 19, 2001

Skin Manifestations of Fabry Disease—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(11):1315. doi:10.1001/jama.286.11.1311

In Reply: In the 6-month trial we reported, the extent of skin angiokeratomas was not among the outcome measures we evaluated. It is unlikely that these lesions would regress, especially after a relatively short period of treatment. It is nevertheless possible that enzyme replacement therapy can prevent the appearance of new angiokeratojldmas. This hypothesis could be tested in future studies.

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