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October 10, 2001

Sexual Transmission During the Incubation Period of Primary HIV Infection

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(14):1713-1714. doi:10.1001/jama.286.14.1709

To the Editor: The concept that peak viremia during primary human immunodeficiency virus (HIV) infection (PHI) could be associated with concurrent high-level genital shedding1,2 has led to the hypothesis that individuals with PHI are highly infectious. This hypothesis would in part explain rapid epidemic spread in populations3 and would suggest that PHI is an important target for public health intervention. We sought to establish that such transmission occurs and to examine the window of infectiousness during PHI.

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