Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
To the Editor: The concept that peak viremia
during primary human immunodeficiency virus (HIV) infection (PHI) could be
associated with concurrent high-level genital shedding1,2
has led to the hypothesis that individuals with PHI are highly infectious.
This hypothesis would in part explain rapid epidemic spread in populations3 and would suggest that PHI is an important target
for public health intervention. We sought to establish that such transmission
occurs and to examine the window of infectiousness during PHI.
Pilcher CD, Eron, Jr JJ, Vemazza PL, Battegay M, Harr T, Yerly S, Vom S, Perrin L. Sexual Transmission During the Incubation Period of Primary HIV Infection. JAMA. 2001;286(14):1713-1714. doi:10.1001/jama.286.14.1709