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October NaN, 2001

Linezolid and Reversible Myelosuppression

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(16):1973-1974. doi:10.1001/jama.286.16.1969

To the Editor: Dr Green and colleagues1 reported serious but reversible myelosuppression in patients receiving more than 2 weeks of therapy with linezolid, with bone marrow changes that appear similar to those seen in reversible chloramphenicol toxicity. The structure and mechanism similarities between linezolid and chloramphenicol suggest there may be a shared mechanism for this adverse effect. Linezolid shares with chloramphenicol an antibacterial mechanism involving binding to the ribosomal RNA of the 50s subunit. They also have structural similarities, including the nitro group hypothesized to be the feature of chloramphenicol responsible for aplastic anemia.2

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