November 14, 2001

Relationship Between Estrogen-Receptor Genotype and Tooth Loss in Postmenopausal Women

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor


Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

JAMA. 2001;286(18):2234-2235. doi:10.1001/jama.286.18.2233

To the Editor: Although tooth loss among elderly patients is known to be influenced by environmental factors, the role of genetic factors is largely unknown. A study of US patients, for instance, found some genetic contribution to the height of alveolar bone that supports the teeth.1 It is likely that the estrogen-receptor (ER) gene could be associated with tooth loss in women because recent studies2,3 suggest that the long-term estrogen replacement therapy (ERT) may protect against tooth loss in elderly women. We investigated the effect of ER genotype on tooth loss and alveolar height in Japanese women.

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