Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
To the Editor: Although tooth loss among elderly
patients is known to be influenced by environmental factors, the role of genetic
factors is largely unknown. A study of US patients, for instance, found some
genetic contribution to the height of alveolar bone that supports the teeth.1 It is likely that the estrogen-receptor (ER) gene
could be associated with tooth loss in women because recent studies2,3 suggest that the long-term estrogen
replacement therapy (ERT) may protect against tooth loss in elderly women.
We investigated the effect of ER genotype on tooth loss and alveolar height
in Japanese women.
Taguchi A, Kobayashi J, Suei Y, Ohtsuka M, Tanimoto K, Sanada M, Ohama K. Relationship Between Estrogen-Receptor Genotype and Tooth Loss in Postmenopausal Women. JAMA. 2001;286(18):2234-2235. doi:10.1001/jama.286.18.2233