Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
Copyright 2001 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2001
In Reply: Our study of the effects of HRT on
bone mineral density in frail, elderly women was initiated in 1995, well before
the results of the HERS study were published.1
When our project began, the prevailing dogma, generated from a wealth of observational
data,2 was that HRT had cardioprotective
effects. Thus, although we excluded women with unstable illness, we did not
exclude those with a history of heart disease. Approximately 10% of the women
who participated in our study had a history of CAD; no cardiovascular events
occurred during the study.
Villareal DT, Binder EB, Williams DB, Schechtman KB, Yarasheski KE, Kohrt WM. Estrogen for Bone Health in Frail Elderly Women—Reply. JAMA. 2001;286(20):2544. doi:10.1001/jama.286.20.2542