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November 28, 2001

Estrogen for Bone Health in Frail Elderly Women—Reply

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(20):2544. doi:10.1001/jama.286.20.2542

In Reply: Our study of the effects of HRT on bone mineral density in frail, elderly women was initiated in 1995, well before the results of the HERS study were published.1 When our project began, the prevailing dogma, generated from a wealth of observational data,2 was that HRT had cardioprotective effects. Thus, although we excluded women with unstable illness, we did not exclude those with a history of heart disease. Approximately 10% of the women who participated in our study had a history of CAD; no cardiovascular events occurred during the study.

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