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November 28, 2001

Influence of Methodological Quality on Study Conclusions

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(20):2544-2547. doi:10.1001/jama.286.20.2542

To the Editor: Dr van Nieuwenhoven and colleagues1 attempted to assess the relationship between trial quality and estimates of treatment for selective digestive decontamination (SDD) of critically ill patients.

Despite their claims about the importance of using rigorous methods of assessment, however, the authors fall short of this standard in several aspects of their analysis, including identification of studies, choice of the instrument for assessing trial quality, and presentation and interpretation of the results.

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