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November 28, 2001

Influence of Methodological Quality on Study Conclusions

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(20):2544-2547. doi:10.1001/jama.286.20.2542

To the Editor: Dr van Nieuwenhoven and colleagues1 demonstrate the importance of methodological quality as a prerequisite of clinical trials. Exaggerated results due to weak methodological quality have been reported for both RCTs and meta-analyses.13

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