Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor
Copyright 2001 American Medical Association. All Rights Reserved.
Applicable FARS/DFARS Restrictions Apply to Government Use.2001
To the Editor: Dr van Nieuwenhoven and colleagues1 demonstrate the importance of methodological quality
as a prerequisite of clinical trials. Exaggerated results due to weak methodological
quality have been reported for both RCTs and meta-analyses.1- 3
Graf J, Janssens U. Influence of Methodological Quality on Study Conclusions. JAMA. 2001;286(20):2544-2547. doi:10.1001/jama.286.20.2542