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November 28, 2001

Influence of Methodological Quality on Study Conclusions

Author Affiliations

Stephen J.LurieMD, PhD, Senior EditorIndividualAuthorJody W.ZylkeMD, Contributing EditorIndividualAuthor

JAMA. 2001;286(20):2544-2547. doi:10.1001/jama.286.20.2542

To the Editor: Dr van Nieuwenhoven and colleagues1 found a relationship between methodological quality score and the apparent benefit of SDD on the incidence of pneumonia. Their study in general agrees with prior examinations of the effects of trial quality, but conflicts somewhat on the contribution of allocation concealment relative to sequence generation and blinding.2,3 That discrepancy might partly arise from confusion in measuring blinding and allocation concealment.

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